This formula is not applicable to the following patients:Īnd during any acute pathology (especially acute renal failure) in general. K: coefficient which is 1 in men and 0.85 in women. Cockcroft and Henry Gault in 1976.Ĭl Cr= ((140 - âge) x poids (kg) )x F) 7,2 x créatininémie (mg/l)Ĭl Cr: estimate of creatinine clearance in mL/min This clearance being very close to the glomerular filtration rate provides information on the state of renal function. The Cockcroft & Gault formula, in medicine, allows the estimation of creatinine clearance in adults. Estimates of glomerular filtration > 75 mL/min. This formula tends to overestimate the actual creatinine clearance and should be used with caution. Measured creatinine should be in steady state. This examination can also be requested after an initial blood test showing high blood creatinine. The original Schwartz formula 1,2 is: CrCl. Both CrCl and GFR can be measured using the comparative. It is a rapid and cost-effective method for the measurement of renal function. Creatinine clearance (CrCl) is the volume of blood plasma cleared of creatinine per unit time. Why prescribe creatinine clearance?Ĭreatinine clearance is prescribed when the kidney disease is suspected, before prescribing medications that involve having normal kidney function, and when renal blood flow is reduced due to heart disease. Alternatively, the biochemical marker creatinine found in serum and urine is commonly used in the estimation of GFR. In the evaluation of clearance, the interpretation should take into account age, sex, weight, height, cardiac and renal function, and drug treatment (salicylates, cimetidine, trimethoprim, probenecid, etc.). Since creatinine is eliminated only by renal filtration, the measurement of its clearance makes it possible to evaluate the filtration rate of the kidneys. Male = 50 kg + (2.3 x (Height in inches - 60))įemale = 45.5 kg + (2.Creatinine clearance measures the ratio between the rate of elimination of creatinine by the kidneys (through urine) and its concentration in the blood. The calculation of the ideal body weight takes place via the Devine formula: These can be adapted for use when serum creatinine is expressed in µmol/L:ĬrCl for men = / (Serum Creatinine in µmol/L)ĬrCl for women = / (Serum Creatinine in µmol/L) The formulas used are gender specific:ĬrCl for men = / (Serum Creatinine in mg/dL x 72)ĬrCl for women = / (Serum Creatinine in mg/dL x 72) The CrCl calculator requires the patient’s gender, age, height and weight and the serum creatinine. The most common method to determine it is via the Cockcroft Gault equation.
14 This equation is most appropriate for patients who are greater than 20-30 of their ideal body weight. This Creatinine Clearance Calculator evaluates renal function via the Cockcroft Gault equation and can offer information on the filtration function of the kidneys.Ĭreatinine clearance is one of the renal indicators of the kidney filtration rate. The most accurate equation for creatinine clearance in obese patients is the Cockcroft-Gault equation with a 40 adjustment factor.
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